Phenotypes Associated with This Genotype

Genotype
MGI:7645366

• Allelic Composition: Tg(CAG-RND2)1Jya/0; Tg(Mbp-cre)9Gvn/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased myelin sheath thickness ( J:309719 )

• myelin sheath thickness is decreased in 28-day-old mice, with increased average g-ratios

increased myelin sheath thickness ( J:309719 )

• myelin sheath thickness is increased in 14-day old mice, with reduced average g-ratios

abnormal myelination ( J:309719 )

• corpus callosum shows increased myelin thickness in 14-day-old mice and decreased myelin thickness in 28-day-old mice

• expression levels of the myelin marker proteins MBP and CNPase are increased in 14-day-old mice but are decreased in brain tissues at P28