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Phenotypes Associated with This Genotype
Genotype
MGI:7645364
Allelic
Composition		 Mrpl12em1Smoc/Mrpl12em1Smoc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrpl12em1Smoc mutation (0 available); any Mrpl12 mutation (14 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal renal tubule epithelium morphology ( J:339098 )
• mitochondria are swollen with rupture of the membrane and distorted cristae

cellular
abnormal mitochondrial morphology ( J:339098 )
• rupture of mitochondrial membranes in renal tubular epithelial cells
abnormal mitochondrial crista morphology ( J:339098 )
• distorted in renal tubular epithelial cells
dilated mitochondrion ( J:339098 )
• swollen mitochondria in renal tubular epithelial cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory