Phenotypes Associated with This Genotype

Genotype
MGI:7643811

• Allelic Composition: Cyp2a12^em1Utr/Cyp2a12^em1Utr
• Genetic Background: C57BL/6J-Cyp2a12^em1Utr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased intestinal cholesterol absorption ( J:302190 )

• intestinal cholesterol absorption, as estimated by serum sitosterol and campesterol, is reduced

abnormal bile salt homeostasis ( J:302190 )

• mice show accumulation of deoxycholic acids (DCAs)

• however, total bile acid pool size is not altered

abnormal enzyme/coenzyme activity ( J:302190 )

• taurodeoxycholic acid (TDCA) 7alpha-hydroxylase activity in the liver is reduced to approximately 10% of wild-type levels

digestive/alimentary system

decreased intestinal cholesterol absorption ( J:302190 )

• intestinal cholesterol absorption, as estimated by serum sitosterol and campesterol, is reduced