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Phenotypes Associated with This Genotype
Genotype
MGI:7639760
Allelic
Composition
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(CAG-cat,-Tcf25)1Xdgz/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Tg(CAG-cat,-Tcf25)1Xdgz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• cardiac hypertrophy induced by aortic banding is blunted with a smaller increase in heart weight , improved cardiac performance, less pronounced hypertrophic morphological changes, and reduced myocardial fibrosis

homeostasis/metabolism
• cardiac hypertrophy induced by aortic banding is blunted with a smaller increase in heart weight , improved cardiac performance, less pronounced hypertrophic morphological changes, and reduced myocardial fibrosis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory