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Phenotypes Associated with This Genotype
Genotype
MGI:7628726
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Thbs4tm1Olsa/Thbs4tm1Olsa
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Thbs4tm1Olsa mutation (0 available); any Thbs4 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in atherosclerotic lesions when fed western diet
• increased CD38+ pro-inflammatory macrophages in atherosclerotic lesions when fed western diet

homeostasis/metabolism
N
• normal plasma LDL/VLDL and HDL levels when fed either western diet or regular chow
• increased free and total cholesterol levels when fed western diet
• normal when fed regular chow
• increased plasma CXCL1 and CCL2 levels when fed western diet

immune system
• in atherosclerotic lesions when fed western diet
• increased CD38+ pro-inflammatory macrophages in atherosclerotic lesions when fed western diet
• increased plasma CXCL1 and CCL2 levels when fed western diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory