Phenotypes Associated with This Genotype

Genotype
MGI:7628239

• Allelic Composition: Mical1^tm1.2Past/Mical1^tm1.2Past
• Genetic Background: involves: C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:299988 )

N • normal left ventricular function at base line and 3, 7 and 14 days after transverse aortic constriction (TAC)

abnormal heartbeat ( J:299988 )

• bradycardia and polymorphic agonal rhythm after transverse aortic constriction (TAC), leading to death

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:299988 )

• 54% of mice die within 4 weeks after transaortic banding (transverse aortic constriction (TAC)), compared to zero WT mice