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Phenotypes Associated with This Genotype
Genotype
MGI:7628219
Allelic
Composition
Tg(PRSS1/lacZ)#Gwzh/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice treated with caerulein to induce nonalcoholic chronic pancreatitis (nACP) show elevated pancreatic acinar steatosis, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha
• mice treated with alcohol to induce alcoholic chronic pancreatitis (ACP) show a greater elevation in pancreatic acinar steatosis than mice just treated with caerulein to induce nACP
• mice with induced ACP show elevated lipid metabolism in pancreatic tissue, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha
• mice treated with parecoxib, a COX-2 inhibitor, before chronic pancreatitis induction with either caerulein or ethanol show protection against acinar injury

endocrine/exocrine glands
• mice with induced ACP show acinar steatosis, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells
• primary acinar cells treated with caerulein or ethanol show decreased viability
• treatment of primary acinar cells treated with caerulein or ethanol with valdecoxib ameliorates the decreased cell viability
• mice treated with caerulein to induce nonalcoholic chronic pancreatitis (nACP) show elevated pancreatic acinar steatosis, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha
• mice treated with alcohol to induce alcoholic chronic pancreatitis (ACP) show a greater elevation in pancreatic acinar steatosis than mice just treated with caerulein to induce nACP
• mice with induced ACP show elevated lipid metabolism in pancreatic tissue, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells, substantial collagen deposition, and elevated levels of inflammatory IL-1beta, Il-6, and TNF-alpha
• mice treated with parecoxib, a COX-2 inhibitor, before chronic pancreatitis induction with either caerulein or ethanol show protection against acinar injury

homeostasis/metabolism
• mice with induced ACP show elevated lipid metabolism in pancreatic tissue, with increased levels of palmitic acid, heptadecanoic acid, stearic acid, and oleic acid (fatty acids) and increased levels of three phospholipid pathway-related metabolites, triglyceride, diglyceride, and cholesterol

digestive/alimentary system
• mice with induced ACP show acinar steatosis, mitochondrial swelling and disruption of the mesenchyme and endoplasmic reticulum in pancreatic acinar cells
• primary acinar cells treated with caerulein or ethanol show decreased viability
• treatment of primary acinar cells treated with caerulein or ethanol with valdecoxib ameliorates the decreased cell viability


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory