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Phenotypes Associated with This Genotype
Genotype
MGI:7627102
Allelic
Composition		 Setd4tm1b(KOMP)Wtsi/Setd4tm1b(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd4tm1b(KOMP)Wtsi mutation (0 available); any Setd4 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased macrophage cytokine production ( J:304151 )
• bone marrow derived macrophages show reduced IL6 and TNF alpha expression in response to LPS, BLP, or Poly(I:C) stimulation
• expression of a broad range of inflammatory cytokines is reduced

hematopoietic system
decreased macrophage cytokine production ( J:304151 )
• bone marrow derived macrophages show reduced IL6 and TNF alpha expression in response to LPS, BLP, or Poly(I:C) stimulation
• expression of a broad range of inflammatory cytokines is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory