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Phenotypes Associated with This Genotype
Genotype
MGI:7623788
Allelic
Composition		 Nfatc2tm1Glm/Nfatc2tm1Glm
Nfatc3tm1c(EUCOMM)Hmgu/Nfatc3tm1c(EUCOMM)Hmgu
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)
Nfatc3tm1c(EUCOMM)Hmgu mutation (1 available); any Nfatc3 mutation (69 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-2 secretion ( J:346703 )
• significantly reduced BPI induced secretion by bone marrow derived cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory