Phenotypes Associated with This Genotype

Genotype
MGI:7622051

• Allelic Composition: Npvf^tm1.1Ubu/Npvf^tm1.1Ubu; Tg(Nes-cre)1Nogu/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:347241 )

♂N • mice show normal spatial working memory in the Y maze test

decreased anxiety-related response ( J:347241 )

♂ • mice spend shorter time in the closed arms of the elevated plus maze test and the number of closed arms entries tends to be decreased while time spent in the open arms is longer and number of open arms entries tends to be increased

hyperactivity ( J:347241 )

♂ • mice perform more intensive exercise after light-off than wild-type mice and this high activity continues for 6 hours (ZT12-18)

hypoactivity ( J:347241 )

♂ • activity tends to be significantly lower during most of the other hours (ZT0-12, 21-24)

♂ • mice show reduced number of arm entries in the Y-maze

increased thermal nociceptive threshold ( J:347241 )

♂ • latency to hindleg licking and jump, but not for foreleg licking, is longer in the hot plate test, indicating reduced sensitivity to pain