Analysis Tools
immune system
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• 4-week-old mice show an increase in peri-insular lymphangiogenesis and Lyve-1+ lymphatic vessel density in the periphery of islets of Langerhans that is comparable to that seen in non-tumorigenic Tg(Ins2-VEGFC)#Pepr transgenic mice, consistent with de novo lymphangiogenesis
• however, no increase in CD31+ blood microvessel density is observed within islets, similar to Tg(Ins2-VEGFC)#Pepr mice, suggesting normal angiogenesis
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