Phenotypes Associated with This Genotype

Genotype
MGI:7608005

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Dusp12^em1Zhzy/Dusp12^em1Zhzy
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardium hypertrophy ( J:345360 )

• aggravated high-fat diet induced myocardial hypertrophy

dilated heart ventricle ( J:345360 )

• aggravated high-fat diet induced enlargement of the ventricular cavities

cardiac fibrosis ( J:345360 )

• aggravated high-fat diet induced cardiac fibrosis

decreased cardiac muscle contractility ( J:345360 )

• aggravated high-fat diet induced reduction in fractional shortening and ejection fraction

cardiomyopathy ( J:345360 )

• aggravated diabetic cardiomyopathy on a high fat diet compared to diet matched controls

homeostasis/metabolism

insulin resistance ( J:345360 )

• expression analysis indicates insulin resistance on a high fat diet

cellular

increased cellular sensitivity to oxidative stress ( J:345360 )

• aggravated oxidative stress injury in response to a high fat diet compared to diet matched controls

growth/size/body

myocardium hypertrophy ( J:345360 )

• aggravated high-fat diet induced myocardial hypertrophy

muscle

myocardium hypertrophy ( J:345360 )

• aggravated high-fat diet induced myocardial hypertrophy

decreased cardiac muscle contractility ( J:345360 )

• aggravated high-fat diet induced reduction in fractional shortening and ejection fraction

cardiomyopathy ( J:345360 )

• aggravated diabetic cardiomyopathy on a high fat diet compared to diet matched controls