Phenotypes Associated with This Genotype

Genotype
MGI:7596327

• Allelic Composition: Slc25a44^em1Kajim/Slc25a44^em1Kajim; Tg(Ucp1-cre)1Evdr/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue physiology ( J:345254 )

• mitochondrial valine oxidation is reduced by 70% in brown adipose tissue (BAT) indicating reduced branched amino acid oxidation

homeostasis/metabolism

impaired febrile response ( J:345254 )

• prostaglandin E2 (PGE2)-induced febrile response is substantially attenuated relative to controls, with lower total heat production and lower maximum temperature

• however, no difference in the velocity of the initial rise in iBAT temperature for the first 5 min after PGE2 administration is seen

growth/size/body

growth/size/body region phenotype ( J:345254 )

N • mice exhibit normal body weight and tissue mass of metabolic organs, including brown adipose tissue, liver, white adipose tissue, and skeletal muscle on a regular chow diet and no differences in brown adipocytes are seen