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Phenotypes Associated with This Genotype
Genotype
MGI:7596078
Allelic
Composition		 A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Sdhaf4em1Bcgen/Sdhaf4em1Bcgen
Genetic
Background		 B6.Cg-Sdhaf4em1Bcgen A1cfTg(Myh6-cre/Esr1*)1Jmk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (37 available)
Sdhaf4em1Bcgen mutation (0 available); any Sdhaf4 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:345348 )
• significantly reduced viability at 8 weeks after tamoxifen treatment

cardiovascular system
enlarged heart ( J:345348 )
• after tamoxifen treatment

growth/size/body
enlarged heart ( J:345348 )
• after tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory