Phenotypes Associated with This Genotype

Genotype
MGI:7587836

• Allelic Composition: Higd1c^em2Chaa/Higd1c^em2Chaa
• Genetic Background: C57BL/6J-Higd1c^em2Chaa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:345095 )

• number of TH-positive glomus cells in the carotid body is similar to wild-type controls

abnormal carotid body physiology ( J:345095 )

• response to hypoxia is attenuated in the carotid sinus nerve

• response to CO2/H+ in the carotid sinus nerve is similar to controls

abnormal type I cell of carotid body physiology ( J:345095 )

• calcium transient responses to hypoxia are weaker compared to wild-type controls

• responses to low pH or high KCL are similar to controls

• mitochondrial membrane responses to hypoxia are attenuated and an increased percentage of cells respond poorly to FCCP, a potent uncoupler of oxidative phosphorylation

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:345095 )

• impaired hypoxic ventilatory response

• however, ventilatory responses to normoxia and hypercapnia are similar to controls

respiratory system

decreased pulmonary ventilation ( J:345095 )

• impaired hypoxic ventilatory response

nervous system

abnormal type I cell of carotid body physiology ( J:345095 )

• calcium transient responses to hypoxia are weaker compared to wild-type controls

• responses to low pH or high KCL are similar to controls

• mitochondrial membrane responses to hypoxia are attenuated and an increased percentage of cells respond poorly to FCCP, a potent uncoupler of oxidative phosphorylation