Phenotypes Associated with This Genotype

Genotype
MGI:7576016

• Allelic Composition: Asxl3^{tm1.1(ASXL3*P723R)Clia}/Asxl3^{tm2.1(ASXL3*P1817A)Clia}
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac muscle tissue morphology ( J:322485 )

• mice exhibit cavernous changes in the left ventricular muscle

abnormal myocardium layer morphology ( J:322485 )

• mice present with incomplete myocardial densification

abnormal myocardial fiber morphology ( J:322485 )

• decrease in cardiomyocyte density

myocardium hypertrophy ( J:322485 )

cardiac fibrosis ( J:322485 )

• increase in cardiac fibrosis

decreased cardiac output ( J:322485 )

decreased cardiac stroke volume ( J:322485 )

decreased cardiac muscle contractility ( J:322485 )

• increase in ejection fraction and fractional shortening

abnormal heart echocardiography feature ( J:322485 )

• mice exhibit a decrease in left ventricular internal diameter end diastole and end systole, in systolic and diastolic volume, in stroke volume, an in cardiac output, and an increase in ejection fraction and fractional shortening

growth/size/body

myocardium hypertrophy ( J:322485 )

muscle

abnormal cardiac muscle tissue morphology ( J:322485 )

• mice exhibit cavernous changes in the left ventricular muscle

abnormal myocardium layer morphology ( J:322485 )

• mice present with incomplete myocardial densification

abnormal myocardial fiber morphology ( J:322485 )

• decrease in cardiomyocyte density

myocardium hypertrophy ( J:322485 )

decreased cardiac muscle contractility ( J:322485 )

• increase in ejection fraction and fractional shortening