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Phenotypes Associated with This Genotype
Genotype
MGI:7573098
Allelic
Composition		 Casp8em1Hbz/Casp8em1Hbz
Ripk1em1Hbz/Ripk1em1Hbz
Ripk3tm1Xidw/Ripk3tm1Xidw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8em1Hbz mutation (0 available); any Casp8 mutation (45 available)
Ripk1em1Hbz mutation (0 available); any Ripk1 mutation (32 available)
Ripk3tm1Xidw mutation (0 available); any Ripk3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

immune system
decreased leukocyte cell number ( J:342732 )
• decreased white blood cell number in peripheral blood
• normal monocyte and granulocyte numbers in peripheral blood
decreased lymphocyte cell number ( J:342732 )
• in peripheral blood
decreased mature B cell number ( J:342732 )
• reduced B220+ IgM+ and B220+ CD19+ B cell numbers in spleen and bone marrow
decreased T cell number ( J:342732 )
• severe reduction in CD3+ CD4+ CD8- and CD3+ CD4- CD8+ T cell in spleen and bone marrow

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory