Phenotypes Associated with This Genotype

Genotype
MGI:7565493

• Allelic Composition: Swhtr^tm1.1Phg/Swhtr^tm1.1Phg
• Genetic Background: either: (involves: C57BL/6J) or (involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to myocardial ischemic injury ( J:342171 )

♂ • male mice of 8 weeks of age show increased mortality after acute myocardial infarction

♂ • following acute myocardial infarction, the intraventricular septum does not show compensatory thickening as is seen in wild-type mice and cell size in the intraventricular septum is decreased indicating a defect in the hypertrophic response after cardiac injury

♂ • however, size of myocardial infarction is similar to that in wild-type mice and cardiac function parameters do not significantly differ from wild-type

♂ • mice exhibit normal heart function, with no differences in ejection fraction, heart rate, or left ventricular diameter

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:342171 )

♂ • male mice of 8 weeks of age show increased mortality after acute myocardial infarction

homeostasis/metabolism

abnormal response to myocardial ischemic injury ( J:342171 )

♂ • male mice of 8 weeks of age show increased mortality after acute myocardial infarction

♂ • following acute myocardial infarction, the intraventricular septum does not show compensatory thickening as is seen in wild-type mice and cell size in the intraventricular septum is decreased indicating a defect in the hypertrophic response after cardiac injury

♂ • however, size of myocardial infarction is similar to that in wild-type mice and cardiac function parameters do not significantly differ from wild-type

♂ • mice exhibit normal heart function, with no differences in ejection fraction, heart rate, or left ventricular diameter

abnormal susceptibility to injury induced morbidity/mortality ( J:342171 )

♂ • male mice of 8 weeks of age show increased mortality after acute myocardial infarction