Phenotypes Associated with This Genotype

Genotype
MGI:7562246

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:199412 )

N • mice are present at the expected Mendelian ratios at E15.5-P0, indicating normal embryonic survival until late gestation or even until birth

cardiovascular system

cardiovascular system phenotype ( J:199412 )

N • at E15.5-P0, none of 10 mice examined exhibit any aortic arch artery remodeling defects

thin right ventricle myocardium compact layer ( J:199412 )

• at E15.5, three of 7 (43%) embryos show thinning of the compact myocardium of the right ventricle

• however, no compact zone thinning is noted in the left ventricle

double outlet right ventricle ( J:199412 )

• at E15.5-P0, one of 7 (14%) embryos exhibits a double outlet right ventricle (DORV)

thick mitral valve cusps ( J:199412 )

• at E15.5, mitral valve leaflets are thickened and hyperplastic in one embryo

mitral valve hyperplasia ( J:199412 )

• at E15.5-P0, one of 7 (14%) embryos shows mitral valve hyperplasia

perimembraneous ventricular septal defect ( J:199412 )

• at E15.5-P0, three of 7 (43%) embryos show a perimembranous VSD

thick pulmonary valve cusps ( J:199412 )

• at P0, pulmonary valve leaflets are thickened and hyperplastic in one embryo

pulmonary valve hyperplasia ( J:199412 )

• at E15.5-P0, one of 7 (14%) embryos shows pulmonary valve hyperplasia

muscle

thin right ventricle myocardium compact layer ( J:199412 )

• at E15.5, three of 7 (43%) embryos show thinning of the compact myocardium of the right ventricle

• however, no compact zone thinning is noted in the left ventricle