Phenotypes Associated with This Genotype

Genotype
MGI:7562242

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Isl1^tm1(cre)Sev/Isl1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:199412 )

N • mice are present at the expected Mendelian ratios at E14.5-P0, indicating normal embryonic survival

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery

retroesophageal right subclavian artery ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aberrant retro-esophageal right subclavian artery

interrupted aortic arch, type b ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit interrupted aortic arch (IAA) type B

abnormal cardiac outflow tract development ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit outflow tract (OFT) defects, including ventricular septal defect (VSD), double outlet right ventricle, and semilunar valve hyperplasia

• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the OFT at E10.5

double outlet right ventricle ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit DORV

ventricular septal defect ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit VSDs

abnormal aortic valve morphology ( J:199412 )

• at E14.5 to P0, six of 8 (75%) embryos exhibit an aortic valve defect

abnormal pulmonary valve morphology ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit a pulmonary valve defect

abnormal pulmonary valve cusp morphology ( J:199412 )

• at PO, pulmonary valve leaflets are enlarged and hyperplastic

semilunar valve hyperplasia ( J:199412 )

• at E14.5 to P0, seven of 8 (88%) embryos exhibit semilunar valve hyperplasia

• however, atrioventricular (mitral and tricuspid) valves are unaffected

embryo

abnormal pharyngeal arch artery morphology ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery

craniofacial

abnormal pharyngeal arch artery morphology ( J:199412 )

• at E14.5 to P0, seven of 22 (32%) embryos exhibit aortic arch artery remodeling defects, including interrupted aortic arch (IAA) type B, hypoplasia of the B segment of the aortic arch, and aberrant retro-esophageal right subclavian artery