Phenotypes for Nkx2-5 Sox7 MGI:7550409 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Sox7^tm1.1Nat/Sox7^tm1.1Nat Nkx2-5^tm2(cre)Rph/Nkx2-5⁺
Genetic Background	involves: 129 * 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm2(cre)Rph mutation (2 available); any Nkx2-5 mutation (22 available)
Sox7^tm1.1Nat mutation (1 available); any Sox7 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:306193 )

atrioventricular cushion hypoplasia ( J:306193 )

• at E9.5, atrioventricular (AV) cushions exhibit significantly lower numbers of mesenchymal cells than control AV cushions, suggesting disruption of endothelial to mesenchymal transition (EndMT)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24