Phenotypes Associated with This Genotype

Genotype
MGI:7546836

• Allelic Composition: Pdcl2^em1Ncvc/Pdcl2^em1Ncvc
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

immotile sperm ( J:338084 )

♂ • spermatozoa are immotile and spermatozoa incubated in a capacitating medium exhibit a severe decrease in overall motility

small seminiferous tubules ( J:338084 )

♂ • lumen of seminiferous tubules is on average smaller than wild-type tubules

small testis ( J:338084 )

♂ • the testis to body weight ratio is reduced

abnormal spermatogenesis ( J:338084 )

♂ • defects in spermatogenesis, with impaired nuclear condensation

♂ • seminiferous tubules show impaired production of spermatids

abnormal sperm flagellum morphology ( J:338084 )

♂ • sperm flagella show deformities

abnormal sperm axoneme morphology ( J:338084 )

♂ • sperm flagella show disrupted axonemes

abnormal sperm midpiece morphology ( J:338084 )

♂ • mature spermatozoa show disorganized mitochondria sequestered in cytoplasmic droplets

♂ • sperm flagella show incomplete midpieces

abnormal sperm head morphology ( J:338084 )

♂ • 100% of spermatozoa have abnormal head shapes

abnormal acrosome assembly ( J:338084 )

♂ • abnormal acrosome biogenesis with lack of acrosomal cap formation

globozoospermia ( J:338084 )

♂ • spermatozoa have round, granular heads, instead of the hook-like shape

absent acrosome ( J:338084 )

♂ • sperm heads have no acrosomal cap

detached acrosome ( J:338084 )

♂ • spermatozoa show abnormal dissociation of the acrosome and the granule during cap biogenesis in the testis

abnormal sperm nucleus morphology ( J:338084 )

♂ • sperm heads have misshapen nuclei

abnormal spermiogenesis ( J:338084 )

♂ • spermatozoa show abnormal dissociation of the acrosome and the granule during cap biogenesis in the testis

♂ • the testicular form of SPACA1 in round spermatids is aberrantly retained indicating abnormal sperm maturation

male infertility ( J:338084 )

♂ • males are sterile despite the formation of copulatory plugs

endocrine/exocrine glands

small seminiferous tubules ( J:338084 )

♂ • lumen of seminiferous tubules is on average smaller than wild-type tubules

small testis ( J:338084 )

♂ • the testis to body weight ratio is reduced

cellular

abnormal sperm flagellum morphology ( J:338084 )

♂ • sperm flagella show deformities

abnormal sperm axoneme morphology ( J:338084 )

♂ • sperm flagella show disrupted axonemes

abnormal sperm midpiece morphology ( J:338084 )

♂ • mature spermatozoa show disorganized mitochondria sequestered in cytoplasmic droplets

♂ • sperm flagella show incomplete midpieces

abnormal sperm head morphology ( J:338084 )

♂ • 100% of spermatozoa have abnormal head shapes

abnormal acrosome assembly ( J:338084 )

♂ • abnormal acrosome biogenesis with lack of acrosomal cap formation

globozoospermia ( J:338084 )

♂ • spermatozoa have round, granular heads, instead of the hook-like shape

absent acrosome ( J:338084 )

♂ • sperm heads have no acrosomal cap

detached acrosome ( J:338084 )

♂ • spermatozoa show abnormal dissociation of the acrosome and the granule during cap biogenesis in the testis

abnormal sperm nucleus morphology ( J:338084 )

♂ • sperm heads have misshapen nuclei

immotile sperm ( J:338084 )

♂ • spermatozoa are immotile and spermatozoa incubated in a capacitating medium exhibit a severe decrease in overall motility