Phenotypes Associated with This Genotype

Genotype
MGI:7543488

• Allelic Composition: Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺
• Genetic Background: involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )

• although present in normal ratios at E15.5/E16.5, heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system

cardiovascular system phenotype ( J:338879 )

N • no ventricular septal defects were identified at E15.5

atrioventricular cushion hypoplasia ( J:338879 )

• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single Sox7^tm1.1Dsco heterozygous controls