Phenotypes Associated with This Genotype

Genotype
MGI:7541054

• Allelic Composition: Tvp23b^em3Eetr/Tvp23b^em3Eetr
• Genetic Background: C57BL/6J-Tvp23b^em3Eetr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased colon goblet cell number ( J:340685 )

abnormal intestinal goblet cell physiology ( J:340685 )

• abrogated mucus layer response to LPS

diarrhea ( J:340685 )

• in mice infected with C. rodentium or treated with DSS

decreased Paneth cell number ( J:340685 )

• absence of granule containing cells in the ileum

increased susceptibility to induced colitis ( J:340685 )

• DSS-treated mice exhibit diarrhea, rectal bleeding, and colonic shortening compared with wild-type mice

• mice infected with C. rodentium exhibit weight loss and diarrhea

growth/size/body

increased susceptibility to weight loss ( J:340685 )

• in mice infected with C. rodentium

endocrine/exocrine glands

decreased colon goblet cell number ( J:340685 )

decreased Paneth cell number ( J:340685 )

• absence of granule containing cells in the ileum

immune system

increased susceptibility to induced colitis ( J:340685 )

• DSS-treated mice exhibit diarrhea, rectal bleeding, and colonic shortening compared with wild-type mice

• mice infected with C. rodentium exhibit weight loss and diarrhea

cellular

decreased colon goblet cell number ( J:340685 )

abnormal intestinal goblet cell physiology ( J:340685 )

• abrogated mucus layer response to LPS