Phenotypes for Gt(ROSA)26Sor Polr1a Tg(Wnt1-cre/Esr1*)10Rth MGI:7526471 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Polr1a^em1Knwea/Polr1a^{tm1c(EUCOMM)Hmgu} Tg(Wnt1-cre/Esr1*)10Rth/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1098 available)
Polr1a^em1Knwea mutation (0 available); any Polr1a mutation (92 available)
Polr1a^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Polr1a mutation (92 available)
Tg(Wnt1-cre/Esr1*)10Rth mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:335489 )

craniofacial

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

growth/size/body

flat forehead ( J:335489 )

• starting in E9.5 embryos, worsening with age

facial cleft ( J:335489 )

cardiovascular system

cardiovascular system phenotype ( J:335489 )

N	• normal outflow tract septation in E12 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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