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Phenotypes Associated with This Genotype
Genotype
MGI:7526470
Allelic
Composition		 Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Polr1aem1Knwea/Polr1atm1c(EUCOMM)Hmgu
Tg(Sox10-cre)1Wdr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1095 available)
Polr1aem1Knwea mutation (0 available); any Polr1a mutation (92 available)
Polr1atm1c(EUCOMM)Hmgu mutation (0 available); any Polr1a mutation (92 available)
Tg(Sox10-cre)1Wdr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
midline cleft upper lip ( J:335489 )
• median lip notches in some E14-E15 embryos
cleft palate ( J:335489 )
• in some E14-E15 embryos
facial cleft ( J:335489 )
• in some E14-E15 embryos

digestive/alimentary system
cleft palate ( J:335489 )
• in some E14-E15 embryos

growth/size/body
midline cleft upper lip ( J:335489 )
• median lip notches in some E14-E15 embryos
cleft palate ( J:335489 )
• in some E14-E15 embryos
facial cleft ( J:335489 )
• in some E14-E15 embryos

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory