Phenotypes for Chd7 Tg(Neurod1-cre)RZ24Gsat MGI:7518243 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Chd7^{tm2c(EUCOMM)Wtsi}/Chd7⁺ Tg(Neurod1-cre)RZ24Gsat/0
Genetic Background	involves: C57BL/6J * C57BL/6N * FVB/NTac
Cell Lines	EPD0019_1_D07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7^{tm2c(EUCOMM)Wtsi} mutation (0 available); any Chd7 mutation (134 available)
Tg(Neurod1-cre)RZ24Gsat mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:314588 )

• some show moderate hearing loss

nervous system

abnormal vestibulocochlear ganglion morphology ( J:314588 )

• slower degeneration of neurons between P1 and P21, reducing numbers to 50% that of controls by P21

neuron degeneration ( J:314588 )

• slower degeneration of spiral ganglion neurons between P1 and P21, reducing numbers to 50% that of controls by P21

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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