Phenotypes Associated with This Genotype

Genotype
MGI:7518227

• Allelic Composition: Chd7^{tm2c(EUCOMM)Wtsi}/Chd7⁺; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
• Cell Lines: EPD0019_1_D07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

cochlear inner hair cell degeneration ( J:314588 )

• rapid degeneration of inner hair cells at P10 and P14

• incidence is reduced compared to homozygous mice (5 of 24 mice)

cochlear outer hair cell degeneration ( J:314588 )

• degeneration of outer hair cells is slower than that of inner hair cells

• incidence is reduced compared to homozygous mice (5 of 24)

increased or absent threshold for auditory brainstem response ( J:314588 )

• only 1 of 7 shows severe-profound hearing loss

nervous system

cochlear inner hair cell degeneration ( J:314588 )

• rapid degeneration of inner hair cells at P10 and P14

• incidence is reduced compared to homozygous mice (5 of 24 mice)

cochlear outer hair cell degeneration ( J:314588 )

• degeneration of outer hair cells is slower than that of inner hair cells

• incidence is reduced compared to homozygous mice (5 of 24)