Analysis Tools
cardiovascular system
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• both sexes of tamoxifen-treated mice fed a Western diet for 12 weeks show a significant decrease in atherosclerotic lesion size in whole aortas as well as smaller lesion areas and less lipid deposition in the aortic sinuses than control mice
• ACTA2 staining of aortic sinuses showed a significant reduction in the vascular smooth muscle cell (VSMC) content of atherosclerotic lesions in both sexes
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homeostasis/metabolism
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• both male and female mice treated with tamoxifen and subsequently fed a Western diet for 12 weeks show no significant differences in plasma glucose levels relative to controls
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• male, but not female, mice treated with tamoxifen and subsequently fed a Western diet for 12 weeks show a modest reduction in plasma cholesterol levels relative to controls
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• female, but not male, mice treated with tamoxifen and subsequently fed a Western diet for 12 weeks exhibit a significant increase in plasma triglyceride levels relative to controls
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