Analysis Tools
cardiovascular system
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• tamoxifen-treated mice fed a Western diet for 12 weeks show a significant decrease in atherosclerotic lesion size in whole aortas as well as smaller lesion areas and less lipid deposition in the aortic sinuses than similarly-fed control mice
• ACTA2 staining showed a significant reduction in the vascular smooth muscle cell (VSMC) content of atherosclerotic lesions in the aortic sinus
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homeostasis/metabolism
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• tamoxifen-treated mice fed a Western diet for 12 weeks show no significant differences in the level of plasma cholesterol, triglycerides, or glucose relative to controls
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