Phenotypes Associated with This Genotype

Genotype
MGI:7495515

• Allelic Composition: Pou2af2^em1Crva/Pou2af2^em1Crva
• Genetic Background: C57BL/6-Pou2af2^em1Crva

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal gastrointestinal brush cell morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the small intestine and partial loss of tuft cells in the colon

• marker analysis shows no detectable tuft cells in the tongue or gallbladder

abnormal respiratory tract brush cell morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the trachea and nasal epithelium

mortality/aging

mortality/aging ( J:325394 )

N • mice are born at normal Mendelian ratios and have indistinguishable weight, morphology, fertility and organ histology from wild-type mice

craniofacial

abnormal tongue epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the tongue

• injection of mice with recombinant IL-25, a cytokine that induces type 2 immune response and tuft cell expansion, is not able to rescue the tuft cell deficiency

abnormal olfactory epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the nasal epithelium

digestive/alimentary system

abnormal gastrointestinal brush cell morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the small intestine and partial loss of tuft cells in the colon

• marker analysis shows no detectable tuft cells in the tongue or gallbladder

abnormal tongue epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the tongue

• injection of mice with recombinant IL-25, a cytokine that induces type 2 immune response and tuft cell expansion, is not able to rescue the tuft cell deficiency

abnormal intestinal epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the small intestine and partial loss of tuft cells in the colon

• however, gastric and thymic tuft cells remain present

endocrine/exocrine glands

abnormal gallbladder epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the gallbladder

growth/size/body

abnormal tongue epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the tongue

• injection of mice with recombinant IL-25, a cytokine that induces type 2 immune response and tuft cell expansion, is not able to rescue the tuft cell deficiency

abnormal olfactory epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the nasal epithelium

liver/biliary system

abnormal gallbladder epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the gallbladder

renal/urinary system

abnormal urethra morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the urethra

respiratory system

abnormal respiratory tract brush cell morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the trachea and nasal epithelium

abnormal respiratory epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the trachea and nasal epithelium

abnormal olfactory epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the nasal epithelium

abnormal trachea morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the trachea

taste/olfaction

abnormal olfactory epithelium morphology ( J:325394 )

• marker analysis shows no detectable tuft cells in the nasal epithelium