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Phenotypes Associated with This Genotype
Genotype
MGI:7494375
Allelic
Composition		 Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Atoh1-cre)1Bfri/0
Tg(Nes-Reln)#Cur/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA * FVB
Cell Lines EPD0019_1_D07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7tm2c(EUCOMM)Wtsi mutation (0 available); any Chd7 mutation (134 available)
Tg(Atoh1-cre)1Bfri mutation (1 available)
Tg(Nes-Reln)#Cur mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:242933 )
N
• overexpression of Reln fully corrects the decrease in granule cell precursors seen in mutant mice without the Reln transgene at P1
abnormal cerebellar lobule formation ( J:242933 )
• overexpression of Reln rescues the decrease in lobule size for lobules VI-VII in female but not male mice
• no difference in Reln expression levels are seen between males and females

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory