Phenotypes Associated with This Genotype

Genotype
MGI:7491815

• Allelic Composition: Chd7^em1Kangn/Chd7^em1Kangn; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:336448 )

• relatively lower survival rate

growth/size/body

decreased body size ( J:336448 )

• smaller size and delayed growth features compared to controls

decreased body weight ( J:336448 )

skeleton

increased bone marrow adipose tissue amount ( J:336448 )

• increase in bone marrow adipose tissue accumulation in both primary and secondary ossification centers

• phenotype is more remarkable in the tibia, with considerable marrow adipose tissue in the mesial region and the distal region is mostly occupied by adipose tissue

abnormal compact bone morphology ( J:336448 )

• diminished cortical bone

decreased osteoblast cell number ( J:336448 )

abnormal trabecular bone morphology ( J:336448 )

• diminished trabecular bone

decreased bone mass ( J:336448 )

decreased bone mineralization ( J:336448 )

• slower bone mineral apposition rate at 4 weeks of age

decreased bone ossification ( J:336448 )

• slower bone formation rate

adipose tissue

increased bone marrow adipose tissue amount ( J:336448 )

• increase in bone marrow adipose tissue accumulation in both primary and secondary ossification centers

• phenotype is more remarkable in the tibia, with considerable marrow adipose tissue in the mesial region and the distal region is mostly occupied by adipose tissue