Phenotypes for Pml Trp53 MGI:7485800 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Pml^tm1Ppp/Pml⁺ Trp53^tm3.1Glo/Trp53^tm3.1Glo
Genetic Background	B6.129S7(Cg)-Pml^tm1Ppp Trp53^tm3.1Glo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pml^tm1Ppp mutation (0 available); any Pml mutation (92 available)
Trp53^tm3.1Glo mutation (0 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:317504 )

• mean survival of male mice is 150 days, i.e., not significantly different from that in males homozygous for Trp53^tm3.1Glo alone (164.5 days)

prenatal lethality, incomplete penetrance ( J:317504 )

• only 12% of females are born, indicating a severe reduction in female survival

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/31/2026 MGI 6.24