Phenotypes Associated with This Genotype

Genotype
MGI:7469798

• Allelic Composition: Kit^W-sh/Kit^W-sh
• Genetic Background: B6.Cg-Kit^W-sh/HNihrJaeBsmGlliJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to type I hypersensitivity reaction ( J:275367 )

• in a model of passive systemic anaphylaxis, mice sensitized i.p. with anti-DNP IgE and challenged with DNP-HAS fail to exhibit induction of hypothermia at 50 min after antigen challenge

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:275367 )

• when sensitized i.p. with anti-DNP IgE and challenged i.p. with DNP-HAS, mice exhibit lack of a mast cell-dependent anaphylactic response with no significant drop in body core temperature noted at 50 min post-challenge