Analysis Tools
nervous system
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• at E18.5, cortices show an apical shift in the expression domain of Cux2, a marker of intermediate progenitors that give rise to upper layer (UL) 2/3 cortical projection neurons (CPNs)
• however, TdTomato levels are largely normal at E14.5, E16.5 and E18.5
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• in culture, primary upper layer CPNs show a progressive reduction in neurite outgrowth and branching complexity
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