Phenotypes Associated with This Genotype

Genotype
MGI:7448524

• Allelic Composition: Rr253^em6Kmm/Rr253^em6Kmm
• Genetic Background: C57BL/6J-Rr253^em6Kmm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:334296 )

N • normal B cell, eosinophil, neutrophil, group 2 innate lymphoid cell (ILC2) and tuft cell development

N • normal common lymphoid progenitors (CLPs) generate plasmacytoid dendritic cells (pDCs) development

N • normal B cell response to infection with Heligmosomoides polygyrus (H. polygyrus)

abnormal common myeloid progenitor cell morphology ( J:334296 )

• MCPs dont generate plasmacytoid dendritic cells (pDCs)

decreased granulocyte monocyte progenitor cell number ( J:334296 )

• reduced number of specified monocyte progenitor cells (cMoPs) in bone marrow

decreased dendritic cell number ( J:334296 )

• very low bone marrow pre-cDC2s and spleen cCD2 numbers

decreased plasmacytoid dendritic cell number ( J:334296 )

increased dendritic cell number ( J:334296 )

• increased bone marrow pre-cDC1 and spleen cCD1 numbers

decreased monocyte cell number ( J:334296 )

• in bone marrow

abnormal T-helper 2 physiology ( J:334296 )

• diminished response and IL4, IL5 and IL13 production after infection with H. polygyrus

immune system

immune system phenotype ( J:334296 )

N • normal B cell, eosinophil, neutrophil, group 2 innate lymphoid cell (ILC2) and tuft cell development

N • normal B cell response to infection with Heligmosomoides polygyrus (H. polygyrus)

decreased dendritic cell number ( J:334296 )

• very low bone marrow pre-cDC2s and spleen cCD2 numbers

decreased plasmacytoid dendritic cell number ( J:334296 )

increased dendritic cell number ( J:334296 )

• increased bone marrow pre-cDC1 and spleen cCD1 numbers

decreased monocyte cell number ( J:334296 )

• in bone marrow

abnormal T-helper 2 physiology ( J:334296 )

• diminished response and IL4, IL5 and IL13 production after infection with H. polygyrus

increased susceptibility to parasitic infection induced morbidity/mortality ( J:334296 )

• failure to form granulomas in small intestine and increased egg burden after infection with Heligmosomoides polygyrus (H. polygyrus)

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:334296 )

• failure to form granulomas in small intestine and increased egg burden after infection with Heligmosomoides polygyrus (H. polygyrus)