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Phenotypes Associated with This Genotype
Genotype
MGI:7439409
Allelic
Composition		 Rr170tm1.1Iku/Rr170tm1.1Iku
Genetic
Background		 B6.Cg-Rr170tm1.1Iku
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased T cell apoptosis ( J:333539 )
• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation
decreased T cell proliferation ( J:333539 )
• impaired homeostatic proliferation of naive T cells: lower absolute numbers of CFSE+ and higher proportion of CFSE-hi and lower proportion of CFSE-int and CFSE-lo CD4+ and CD8+ T cells in slowly dividing population in transplantation experiments

hematopoietic system
hematopoietic system phenotype ( J:333539 )
N
• normal absolute and relative number of CLPs (common lymphoid progenitors) in Hardy fractions A-F
• normal number of bone marrow cells
increased T cell apoptosis ( J:333539 )
• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation
decreased T cell proliferation ( J:333539 )
• impaired homeostatic proliferation of naive T cells: lower absolute numbers of CFSE+ and higher proportion of CFSE-hi and lower proportion of CFSE-int and CFSE-lo CD4+ and CD8+ T cells in slowly dividing population in transplantation experiments
decreased T cell number ( J:333539 )
• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation

immune system
immune system phenotype ( J:333539 )
N
• normal number of bone marrow cells
• normal absolute and relative number of CLPs (common lymphoid progenitors) in Hardy fractions A-F
increased T cell apoptosis ( J:333539 )
• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation
decreased T cell proliferation ( J:333539 )
• impaired homeostatic proliferation of naive T cells: lower absolute numbers of CFSE+ and higher proportion of CFSE-hi and lower proportion of CFSE-int and CFSE-lo CD4+ and CD8+ T cells in slowly dividing population in transplantation experiments
decreased T cell number ( J:333539 )
• reduced survival of CD4+ and CD8+ peripheral T cells after Il7 stimulation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory