Phenotypes Associated with This Genotype

Genotype
MGI:7437556

• Allelic Composition: Rr364^tm1.1Aak/Rr364^tm1.1Aak
• Genetic Background: 129.129S2(Cg)-Rr364^tm1.1Aak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal class switch recombination ( J:242276 )

• reduced Ighg3 and increased Ighg2b surface expression when CD43- splenic B cells were induced to switch

• reduced switching to Ighg3 and increased switching to Ighg2b in LPS-stimulated pro-B cells

• normal Ighg2a and Ighg1 surface expression when CD43- splenic B cells were induced to switch

• reduced Ighg3 and increased Ighg2a and Ighg2b serum levels 28 days after immunization with TNP-Ficoll

increased IgG2a level ( J:242276 )

• increased Ighg2a serum levels 28 days after immunization with TNP-Ficoll

• normal Ighg2a surface expression when CD43- splenic B cells were induced to switch

increased IgG2b level ( J:242276 )

• increased Ighg2b surface expression when CD43- splenic B cells were induced to switch

• increased Ighg2b serum levels 28 days after immunization with TNP-Ficoll

decreased IgG3 level ( J:242276 )

• reduced Ighg3 surface expression when CD43- splenic B cells were induced to switch

• reduced Ighg3 serum levels 28 days after immunization with TNP-Ficoll

immune system

abnormal class switch recombination ( J:242276 )

• reduced Ighg3 and increased Ighg2b surface expression when CD43- splenic B cells were induced to switch

• reduced switching to Ighg3 and increased switching to Ighg2b in LPS-stimulated pro-B cells

• normal Ighg2a and Ighg1 surface expression when CD43- splenic B cells were induced to switch

• reduced Ighg3 and increased Ighg2a and Ighg2b serum levels 28 days after immunization with TNP-Ficoll

increased IgG2a level ( J:242276 )

• increased Ighg2a serum levels 28 days after immunization with TNP-Ficoll

• normal Ighg2a surface expression when CD43- splenic B cells were induced to switch

increased IgG2b level ( J:242276 )

• increased Ighg2b surface expression when CD43- splenic B cells were induced to switch

• increased Ighg2b serum levels 28 days after immunization with TNP-Ficoll

decreased IgG3 level ( J:242276 )

• reduced Ighg3 surface expression when CD43- splenic B cells were induced to switch

• reduced Ighg3 serum levels 28 days after immunization with TNP-Ficoll