Phenotypes Associated with This Genotype

Genotype
MGI:7430740

• Allelic Composition: Arb2a^{Tg(Tyr)TpNpln}/Arb2a^{Tg(Tyr)TpNpln}; Gata4^tm1(cre)Svs/Gata4⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal neural crest cell migration ( J:260599 )

• neural crest cells accumulate in the vicinity of the dorsal neural tube, migrate more slowly, and oscillate rather than persist in their ventrally oriented migration

• neural crest cell speed and directionality at the leading edge of migration streams are impaired

• hindgut colonization by enteric neural crest cells of vagal origin is delayed at E13.5 but not at E15.5

embryo

abnormal neural crest cell migration ( J:260599 )

• neural crest cells accumulate in the vicinity of the dorsal neural tube, migrate more slowly, and oscillate rather than persist in their ventrally oriented migration

• neural crest cell speed and directionality at the leading edge of migration streams are impaired

• hindgut colonization by enteric neural crest cells of vagal origin is delayed at E13.5 but not at E15.5