Phenotypes Associated with This Genotype

Genotype
MGI:7410887

• Allelic Composition: Arih1^em3Gpt/Arih1^em3Gpt; Lyz2^em1(icre)Gpt/Lyz2⁺
• Genetic Background: C57BL/6JGpt-Arih1^em3Gpt Lyz2^em1(icre)Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:330879 )

immune system

immune system phenotype ( J:330879 )

N • in vitro differentiation of bone marrow derived dendritic cells and bone marrow derived macrophages is normal

decreased circulating interferon-beta level ( J:330879 )

• in HSV-1-infected mice

decreased circulating interleukin-6 level ( J:330879 )

• in HSV-1-infected mice

decreased interferon-beta secretion ( J:330879 )

• in bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA

• however, bone marrow derived dendritic cells exhibit normal production of IFN-beta in response to SeV-, poly(I:C)-, or cGAMP

decreased interleukin-6 secretion ( J:330879 )

• in bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA

• however, bone marrow derived dendritic cells exhibit normal production of IL6 in response to SeV-, poly(I:C)-, or cGAMP

increased susceptibility to Herpesvirales infection ( J:330879 )

• bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA produce less IFN-beta and IL6

• HSV-1-infected mice exhibit increased viral titer in the brain, decreased IFN-beta and IL6 sera levels, and increased mortality compared with control mice

• however, bone marrow derived dendritic cells exhibit normal production of IFN-beta and IL6 in response to SeV-, poly(I:C)-, or cGAMP

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:330879 )

homeostasis/metabolism

decreased circulating interferon-beta level ( J:330879 )

• in HSV-1-infected mice

decreased circulating interleukin-6 level ( J:330879 )

• in HSV-1-infected mice