Phenotypes Associated with This Genotype

Genotype
MGI:7407208

• Allelic Composition: Magee2^{em1(IMPC)Wtsi}/Y
• Genetic Background: C57BL/6N-Magee2^{em1(IMPC)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased brain size ( J:324106 )

♂ • total brain area is increased by +13%

♂ • width of the brain is increased by +9%

♂ • height of rostral brain is increased by +9%

♂ • height of caudal brain is increased by +7%

increased anterior commissure size ( J:324106 )

♂ • area of the anterior part of the anterior commissure is increased by +11%

increased superior colliculus size ( J:324106 )

♂ • area of the superior colliculus is increased by +14%

increased pons size ( J:324106 )

♂ • height of the pons is increased by +6%

abnormal retrosplenial granular cortex morphology ( J:324106 )

♂ • granular retrosplenial cortex total area is significantly enlarged (+34%) due to a combined increase in total cell count (+18%) and average cell area (+14%); as a result, measured cell density is lower than that in wild-type controls (-12%)

increased retrosplenial granular cortex size ( J:324106 )

♂ • area of the granular retrosplenial cortex is the most severely affected brain structure showing an enlargement of +34%

increased hippocampal fimbria size ( J:324106 )

♂ • area of the hippocampal fimbria is increased by +27%

increased primary motor cortex size ( J:324106 )

♂ • height of the primary motor cortex is increased by +11%

growth/size/body

growth/size/body region phenotype ( J:324106 )

♂N • at 4 to 16 weeks of age, hemizygous males exhibit no significant alterations in body weight relative to wild-type controls

megacephaly ( J:324106 )

♂ • on a parasagittal brain section at plane Lateral +0.60 mm, hemizygous males display mild to severe brain anomalies reminiscent of macrocephaly at 16 weeks of age