Phenotypes Associated with This Genotype

Genotype
MGI:7398160

• Allelic Composition: Wtip^Gt(XH617)Byg/Wtip⁺
• Genetic Background: FVB.129P2(B6)-Wtip^Gt(XH617)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased urine protein level ( J:327589 )

• at 3 days after a single tail vein injection of adriamycin (20 mg/kg), 6- to 8-wk-old heterozygotes exhibit significantly higher levels of albuminuria than similarly treated wild-type controls

increased susceptibility to injury ( J:327589 )

• in response to adriamycin-induced kidney injury, heterozygotes on the FVN background show significantly higher levels of albuminuria, diffuse podocyte foot process effacement, and lower glomerular nephrin expression at 3 days after tail vein injection of adriamycin (20 mg/kg) than similarly treated wild-type controls

• Background Sensitivity: heterozygotes on the C57BL/6 background do not develop albuminuria after tail vein injection of adriamycin

renal/urinary system

increased urine protein level ( J:327589 )

• at 3 days after a single tail vein injection of adriamycin (20 mg/kg), 6- to 8-wk-old heterozygotes exhibit significantly higher levels of albuminuria than similarly treated wild-type controls

podocyte foot process effacement ( J:327589 )

• at 3 days after a single tail vein injection of adriamycin (20 mg/kg), heterozygotes develop diffuse podocyte foot process effacement, unlike similarly treated wild-type controls which retain normal foot process morphology