Phenotypes Associated with This Genotype

Genotype
MGI:7398156

• Allelic Composition: Wtip^Gt(XH617)Byg/Wtip⁺
• Genetic Background: B6.129P2-Wtip^Gt(XH617)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased urine protein level ( J:327589 )

• at 6 and 24 h after i.p. injection of LPS, 6- to 8-wk-old heterozygotes develop significantly higher levels of proteinuria than similarly treated wild-type controls

increased susceptibility to injury ( J:327589 )

• in response to LPS-induced kidney injury, heterozygotes on the C57BL/6 background develop significantly higher levels of proteinuria at 6 and 24 h after i.p. injection of LPS than similarly treated wild-type controls

• however, heterozygotes on the C57BL/6 background do not develop albuminuria after tail vein injection of adriamycin, similar to wild-type controls

renal/urinary system

renal/urinary system phenotype ( J:327589 )

N • heterozygotes show no evidence of spontaneous proteinuria at 6-8 weeks of age and do not develop glomerular pathology up to 12 months of age

increased urine protein level ( J:327589 )

• at 6 and 24 h after i.p. injection of LPS, 6- to 8-wk-old heterozygotes develop significantly higher levels of proteinuria than similarly treated wild-type controls