Phenotypes Associated with This Genotype

Genotype
MGI:7378804

• Allelic Composition: Vps35^tm1.1Mjff/Vps35⁺
• Genetic Background: B6.Cg-Vps35^tm1.1Mjff

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal nervous system dopamine level ( J:274797 )

• Increased dopamine release in dorsolateral striatal slices as measured by fast scan cyclic voltammetry; in heterozygote increase is less than in homozygote, but higher than in wild-type

• Decay time of dopamine transient is slower in dorsolateral striatal slices

• Increased dopamine turnover as measured by ration of dopamine metabolites to dopamine

• In response to a D2 agonist, quinpirole, dorsolateral striatal slices exhibit a more rapid inhibition of dopamine release

nervous system

abnormal nervous system dopamine level ( J:274797 )

• Increased dopamine release in dorsolateral striatal slices as measured by fast scan cyclic voltammetry; in heterozygote increase is less than in homozygote, but higher than in wild-type

• Decay time of dopamine transient is slower in dorsolateral striatal slices

• Increased dopamine turnover as measured by ration of dopamine metabolites to dopamine

• In response to a D2 agonist, quinpirole, dorsolateral striatal slices exhibit a more rapid inhibition of dopamine release