Phenotypes Associated with This Genotype

Genotype
MGI:7378518

• Allelic Composition: Zic3^Bn/0
• Genetic Background: involves: BNT/LeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:101328 )

♂N • mice exhibit normal behavior on the rotating rod, forced swimming, Morris Water Maze, and elevated-plus maze tests

abnormal horizontal vestibuloocular reflex ( J:101328 )

♂ • mice exhibit a reduction in gains of the horizontal vestibulo-ocular and optokinetic reflex tests as well as depressed adaptability of horizontal optokinetic reflex compared with wild-type mice

♂ • however, there is no difference in the phases

impaired coordination ( J:101328 )

♂ • shorter retention time in the wire-hanging test

♂ • however, grip strength is normal

hypoactivity ( J:101328 )

♂ • reduced horizontal motor activity in an open space

hearing/vestibular/ear

abnormal horizontal vestibuloocular reflex ( J:101328 )

♂ • mice exhibit a reduction in gains of the horizontal vestibulo-ocular and optokinetic reflex tests as well as depressed adaptability of horizontal optokinetic reflex compared with wild-type mice

♂ • however, there is no difference in the phases

nervous system

abnormal cerebellar hemisphere morphology ( J:101328 )

♂ • reduced size of the parafloccus-floccus complex

abnormal cerebellum vermis lobule III morphology ( J:101328 )

♂ • severely reduced size of the anterior central lobe

abnormal cerebellum vermis lobule V morphology ( J:101328 )

♂ • reduced size

cerebellum vermis hypoplasia ( J:101328 )

♂ • marked in the anterior lobe (lobules I-V) and in the uvula (IX) and nodule (X)

♂ • however, folial patterning is normal