Phenotypes Associated with This Genotype

Genotype
MGI:7367286

• Allelic Composition: Rr303^em1Vave/Rr303^em1Vave
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:308878 )

N • normal firing rate, minimum diastolic potential, and early diastolic depolarization in isolated cardiac pacemaker cells (PCs)

abnormal sinoatrial node morphology ( J:308878 )

• reduced number of cardiac pacemaker cells (PCs) both in and away from sinoatrial node (SAN) in E14.5 embryos

• reduced area/volume of sinoatrial node (SAN) head in E14.5 embryos

increased heart rate variability ( J:308878 )

♀ • during periods of high activity

decreased heart rate ( J:308878 )

• especially during periods of low activity

sinus bradycardia ( J:308878 )

irregular heartbeat ( J:308878 )

embryo

embryo phenotype ( J:308878 )

N • viable

muscle

abnormal sinoatrial node morphology ( J:308878 )

• reduced number of cardiac pacemaker cells (PCs) both in and away from sinoatrial node (SAN) in E14.5 embryos

• reduced area/volume of sinoatrial node (SAN) head in E14.5 embryos