Analysis Tools
behavior/neurological
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• young adult mice exhibit a longer latency to find the target hole in the training phases of day 2 in the Barnes Maze
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• young adult mice exhibit reduced spontaneous alternation in the Y-maze
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reproductive system
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• half of the epididymal lumens have decreased amount of sperm or are almost empty
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• sperm exhibit abnormalities such as coiled/winding flagella, irregular shapes, and missing head
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• some sperm show coiled/winding flagella
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• some sperm exhibit missing heads
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• sperm are less motile
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small testis
(
J:330082
)
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• dramatic increase in cell death in testes
• R-loop and DNA damage levels are much higher and the levels of ciR-loop are increased in the testes
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• about half of males are infertile
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nervous system
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• decrease in neuron numbers in the hippocampus
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• decrease in neuron numbers in the hippocampus
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• increase in DNA damage in the hippocampus
• increase of circRNA:DNA formation (ciR-loop) levels in the hippocampus
• overall RNA:DNA (R-loop) levels are increased in the hippocampus
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endocrine/exocrine glands
small testis
(
J:330082
)
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• dramatic increase in cell death in testes
• R-loop and DNA damage levels are much higher and the levels of ciR-loop are increased in the testes
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cellular
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• half of the epididymal lumens have decreased amount of sperm or are almost empty
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• sperm exhibit abnormalities such as coiled/winding flagella, irregular shapes, and missing head
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• some sperm show coiled/winding flagella
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• some sperm exhibit missing heads
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• dramatic increase in cell death in testes
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• sperm are less motile
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