Phenotypes for Sp7 Zfhx4 MGI:7344366 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sp7^tm1.1Rnis/Sp7⁺ Zfhx4^tm1.1Rnis/Zfhx4^tm1.1Rnis
Genetic Background	involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp7^tm1.1Rnis mutation (0 available); any Sp7 mutation (21 available)
Zfhx4^tm1.1Rnis mutation (0 available); any Zfhx4 mutation (155 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased chondrocyte number ( J:316165 )

• decrease in the number of hypertrophic chondrocytes at E16.5 that is more sever compared to mutant mice wild-type for Sp7

abnormal endochondral bone ossification ( J:316165 )

• impairment of calcification of the femur is more sever at E16.5 compared to mutant mice wild-type for Sp7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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