Analysis Tools
reproductive system
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• surprisingly, heterozygous male mice show normal testis morphology and weight and are fertile, unlike the infertile heterozygous Septin12tm1.1Plk male chimeras reported in J:147965
• after intracytoplasmic sperm injection (ICSI), 69% of wild-type oocytes injected with heterozygous sperm develop to 2-cell embryos and only 8.6% develop to the blastocyst stage, indicating that sperm quality is slightly impaired only under sub-optimal in vitro conditions
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